A compact vocabulary of paratope-epitope interactions enables predictability of antibody-antigen binding
Rahmad Akbar, Philippe A. Robert, Milena Pavlović, Jeliazko R. Jeliazkov, Igor Snapkov, Andrei Slabodkin, Cédric R. Weber, Lonneke Scheffer, Enkelejda Miho, Ingrid Hobæk Haff, Dag Trygve Tryslew Haug, Fridtjof Lund‐Johansen, Yana Safonova, Geir Kjetil Sandve, Victor Greiff
Abstract
motifs; (2) distinct from non-immune protein-protein interactions; and (3) mediates specific oligo- and polyreactive interactions between paratope-epitope pairs. Our work leverages combined structure- and sequence-based learning to demonstrate that machine-learning-driven predictive paratope and epitope engineering is feasible.
Topics & Concepts
ParatopeEpitopeAntigenAntibodyComputational biologyComputer scienceBiologyImmunologyMonoclonal and Polyclonal Antibodies ResearchGlycosylation and Glycoproteins Researchvaccines and immunoinformatics approaches