Pomegranate (<i>Punica granatum</i>) Fruit Extract Suppresses Cancer Progression and Tumor Angiogenesis of Pancreatic and Colon Cancer in Chick Chorioallantoic Membrane Model
Thangirala Sudha, Deena S. Mousa, Ali H. El‐Far, Shaker A. Mousa
Abstract
Pomegranate fruit extract contains many polyphenols and flavonoids of diverse biological importance including anticancer potential. In cancer, the angiogenesis process facilitates solid cancer growth and metastasis. Here, the antiangiogenic effect of pomegranate fruit extract against human pancreatic cancer (Suit-2) and colon (colo205) cell lines in the chick chorioallantoic membrane (CAM) model was studied along with the effect of pomegranate fruit extract on fibroblast growth factor (FGF2). Pomegranate fruit extract significantly reduced the tumor weight and hemoglobin content in CAM models of pancreatic Suit-2 and colon colo205.
Topics & Concepts
PunicaAngiogenesisChorioallantoic membranePancreatic cancerColorectal cancerMetastasisTraditional medicinePolyphenolCancerCancer researchMedicineBiologyBiochemistryInternal medicineAntioxidantPomegranate: compositions and health benefitsKruppel-like factors researchAngiogenesis and VEGF in Cancer