Efficient Generation of Dopaminergic Neurons from Mouse Ventral Midbrain Astrocytes
Jin Yi Han, Eun Hye Lee, Sangmi Kim, Chang‐Hwan Park
Abstract
and additional transcription factors genes such as superoxide dismutase 1 and SRY-box 2. Here, we demonstrate that astrocytes isolated from the ventral midbrain, the origin of SN DA neurons, can be effectively converted into DA neurons and NPCs with enhanced viability. In addition, when these NPCs are inducted to differentiate, they exhibit key characteristics of DA neurons. Thus, direct conversion of midbrain astrocytes is a possible cell therapy strategy to treat neurodegenerative diseases.
Topics & Concepts
MidbrainSubstantia nigraDopaminergicReprogrammingBiologyNeuroscienceCell biologyNeural stem cellOxidopamineProgenitor cellTranscription factorStem cellDopamineCellCentral nervous systemGeneBiochemistryPluripotent Stem Cells ResearchNuclear Receptors and SignalingCRISPR and Genetic Engineering