Sensitive and specific detection of peroxynitrite and <i>in vivo</i> imaging of inflammation by a “simple” AIE bioprobe
Huilin Xie, Jingtian Zhang, Chao Chen, Feiyi Sun, Haixiang Liu, Xinyuan He, Kristy W. K. Lam, Zhao Li, Jacky W. Y. Lam, Guoqiang Zhang, Dan Ding, Ryan T. K. Kwok, Ben Zhong Tang
Abstract
A facile synthesized AIE bioprobe was developed to detect peroxynitrite sensitively and specifically. This bioprobe can realize both <italic>in vitro</italic> ONOO<sup>−</sup> detection and <italic>in vivo</italic> visualization of inflammation.
Topics & Concepts
PeroxynitriteIn vivoChemistryInflammationNanotechnologyMedicineMaterials scienceBiochemistryBiologyImmunologyGeneticsEnzymeSuperoxideMolecular Sensors and Ion DetectionLuminescence and Fluorescent MaterialsSulfur Compounds in Biology