Electrosynthesis of C3 Alkoxylated Quinoxalin‐2(1<i>H</i>)‐ones through Dehydrogenative C–H/O–H Cross‐Coupling
Xinpeng Jiang, Liechao Yang, Zenghui Ye, Xiaofan Du, Liyun Fang, Yu Zhu, Keda Chen, Jianjun Li, Chuanming Yu
Abstract
A highly efficient electrochemically dehydrogenative C–H/O–H cross‐coupling between quinoxalin‐2(1 H )‐ones and alcohols was developed under mild conditions. Using different types of alcohols as solvent, various 3‐alkoxylated quinoxalin‐2(1 H )‐ones were synthesized in a simple undivided cell at room temperature. This novel electrochemical cross‐dehydrogenative coupling approach features broad functional group tolerance, metal‐ and oxidant‐free conditions, and moderate to good yields.
Topics & Concepts
ChemistryElectrosynthesisElectrochemistrySolventCoupling (piping)MetalFunctional groupCombinatorial chemistryOrganic chemistryPhysical chemistryElectrodeMechanical engineeringPolymerEngineeringSynthesis and Biological EvaluationRadical Photochemical ReactionsCatalytic C–H Functionalization Methods