The immune system view of the coronavirus SARS-CoV-2
Ivana Celardo, Luigia Pace, Loredana Cifaldi, Carlo Gaudio, Vincenzo Barnaba
Abstract
Knowing the "point of view" of the immune system is essential to understand the characteristic of a pandemic, such as that generated by the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)-2, responsible for the Coronavirus Disease (COVID)-19. In this review, we will discuss the general host/pathogen interactions dictating protective immune response or immunopathology, addressing the role of immunity or immunopathology in influencing the clinical infection outcome, and debate the potential immunoprophylactic and immunotherapy strategies required to fight the virus infection.
Topics & Concepts
ImmunopathologyBiologyImmune systemPandemicCoronavirusImmunologyImmunitySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)Disease2019-20 coronavirus outbreakVirologyImmunotherapyBetacoronavirusViral diseaseVirusInfectious disease (medical specialty)MedicinePathologyOutbreakSARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesCOVID-19 and Mental Health