Arsenic impairs the lineage commitment of hematopoietic progenitor cells through the attenuation of GATA-2 DNA binding activity
Sebastian Medina, Haikun Zhang, Laura V. Santos-Medina, Guanghua Wan, Alicia M. Bolt, Xixi Zhou, Scott W. Burchiel, Ke Jian Liu
Topics & Concepts
HaematopoiesisErythropoiesisProgenitor cellBiologyCell biologyTranscription factorZinc fingerChromatin immunoprecipitationBone marrowGATA2Cancer researchStem cellImmunologyGeneticsGeneGene expressionAnemiaPromoterInternal medicineMedicineAcute Myeloid Leukemia ResearchHemoglobinopathies and Related DisordersPrenatal Screening and Diagnostics