A novel approach for the synthesis of β-keto esters: one-pot reaction of carboxylic acids with chlorosulfonyl isocyanate

Abstract

-Keto esters were synthesized by direct carboxylation of various 4-and 5-oxo-carboxylic acid derivatives in the presence of chlorosulfonyl isocyanate in excellent yield under mild conditions. Additionally, optimization conditions were examined for synthesis -keto esters. Finally, it has been found that trifluoroacetic acid is efficient in DCM under optimized conditions. This efficient one-pot novel method is very usefull, fair price and easy to handle of -keto esters.

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