Implementation of analytical quality by design and green chemistry principles to develop an ultra-high performance liquid chromatography method for the determination of Fluocinolone Acetonide impurities from its drug substance and topical oil formulations
Siva Krishna Muchakayala, Naresh Kumar Katari, Kalyan Kumar Saripella, Henele Schaaf, Vishnu Murthy Marisetti, Santhosh Kumar Ettaboina, Vijay Kumar Rekulapally
Topics & Concepts
ChemistryChromatographyGradient elutionCentral composite designHigh-performance liquid chromatographyQuality by DesignFluocinolone acetonideImpurityAnalytical Chemistry (journal)Response surface methodologyOrganic chemistryPhysical chemistryMedicineParticle sizeOphthalmologyAnalytical Methods in PharmaceuticalsAnalytical Chemistry and ChromatographyAntibiotics Pharmacokinetics and Efficacy