Determination of sitagliptin in human plasma using a smart electrochemical sensor based on electroactive molecularly imprinted nanoparticles
Isma Haq, Kaseb D. Alanazi, Joanna Czulak, Sabrina Di Masi, Elena Piletska, Adnan Mujahid, Tajamal Hussain, Sergey A. Piletsky, Álvaro García‐Cruz
Abstract
towards sitagliptin, and the limit of detection of the fabricated sensor was found to be 0.06 pM. The sensor displayed a satisfactory performance for the determination of sitagliptin in spiked human plasma, demonstrating the potential of this technology for drug monitoring and clinical diagnosis.
Topics & Concepts
Molecularly imprinted polymerDifferential pulse voltammetryDynamic light scatteringCyclic voltammetryBiosensorDielectric spectroscopyMaterials scienceChemistryAnalyteNanoparticleNanotechnologyElectrochemistryChromatographyOrganic chemistryElectrodeSelectivityPhysical chemistryCatalysisAnalytical Methods in PharmaceuticalsAnalytical chemistry methods developmentElectrochemical sensors and biosensors