AMPK-PDZD8-GLS1 axis mediates calorie restriction-induced lifespan extension
Mengqi Li, Yu Wang, Xiaoyan Wei, Wei-Feng Cai, Yan‐Hui Liu, Jianfeng Wu, Yan Chen, Jinye Xiong, Lifeng Cui, Mingxia Zhu, Cixiong Zhang, Liyun Lin, Yong Yu, Hai‐long Piao, Sheng‐Cai Lin, Chen‐Song Zhang, Chen‐Song Zhang, Chen‐Song Zhang
Abstract
Calorie restriction (CR) that chronically reduces average daily caloric intake without causing malnutrition has been recognized as a non-pharmacological dietary behavior for improving health. 1 The benefits of CR have been observed in various species, including yeast, nematodes, mice, and primates, showing a general link between reduced food intake and longevity. 2 During CR, organisms undergo metabolic changes or adaptations, such as a shift from primarily consuming glucose to fatty acid and amino acid catabolism. 3 , 4 However, the mechanism behind these adaptations and their relationship to the lifespan extension mediated by CR remains largely unknown.