Synthesis and in vitro biological evaluation of 3-ethyl-1,5-naphthyridin-2(1H)-one derivatives as potent PARP-1 selective inhibitors and PARP-1 DNA trappers
Junkang Ren, Quan Xu, Ying Liu, Jiani Li, Xiaoyu Zhang, Xiaoyu Zhang, Zhiyu Li, Xiaomeng Zhang, Xiaomeng Zhang
Topics & Concepts
Poly ADP ribose polymeraseChemistryDNAIn vitroMutantDNA repairPARP inhibitorMolecular biologyDNA damagePolymeraseStereochemistryBiochemistryGeneBiologyPARP inhibition in cancer therapyPlant Genetic and Mutation StudiesDNA Repair Mechanisms