Palladium-Catalyzed Stereoselective 1,3-Diarylation of 1,4-Cyclohexadiene
Hai‐Liang Pang, Donghai Wu, Guoyin Yin
Abstract
A palladium-catalyzed migratory diarylation of unconjugated cyclohexadiene is disclosed, which exihibits high 1,3-regioselectivity and exclusive cis-diastereoselectivity. The excellent selectivity suggests that the olefin does not dissocate from the palladium during chain-walking. This study provides a simple method for the synthesis of 1,3-diaryl-substituted cyclohexanes
Topics & Concepts
ChemistryStereoselectivityPalladiumCatalysisMedicinal chemistryOrganic chemistryCombinatorial chemistrySynthetic Organic Chemistry MethodsAsymmetric Synthesis and CatalysisChemical Synthesis and Analysis