Detection of Antinephrin Antibodies in Childhood Idiopathic Nephrotic Syndrome
Gaia Bianchi, William Morello, Elisa Pesce, Alfredo Berrettini, Giovanni Montini, Federica Collino
Abstract
Idiopathic nephrotic syndrome (INS) is the most frequent glomerular disease in children entailing an intense treatment with steroids and other immunosuppressive drugs. Based on the response to first-line treatment with steroids, INS in children is classified as steroid-resistant (SRNS) or steroid-sensitive (SSNS).1 Most INS cases have multifactorial pathogenesis involving immunological, genetic, and epigenetic factors.S1,S2 Currently, a biomarker, associated with INS pathophysiology, that is able to predict the clinical course of the disease (response to treatment and occurrence of relapses) is lacking.
Topics & Concepts
MedicineNephrinIdiopathic Nephrotic SyndromeNephrotic syndromeAntibodyImmunologyInternal medicinePodocyteProteinuriaKidneyRenal Diseases and GlomerulopathiesAutoimmune Bullous Skin DiseasesPlatelet Disorders and Treatments