Dearomatizing Amination Reactions
Changcheng Jing, Joshua J. Farndon, John F. Bower
Abstract
Abstract Dearomatization reactions allow the direct synthesis of structurally complex sp 3 ‐rich molecules from readily available “flat” precursors. Established dearomatization processes commonly involve the formation of new C−C bonds, whereas methods that enable the introduction of C−N bonds have received less attention. Because of the privileged position of nitrogen in drug discovery, significant recent methodological efforts have been directed towards addressing this deficiency. Consequently, a variety of new processes are now available that allow the direct preparation of sp 3 ‐rich amino‐containing building blocks and scaffolds. This review gives an overview of C−N bond forming dearomatization reactions, particularly with respect to scaffold assembly processes. The discussion gives historical context, but the main focus is on selected methods that have been reported recently.