CD169+ lymph node macrophages have protective functions in mouse breast cancer metastasis
Carlotta Tacconi, Catharina D. Commerford, Lothar C. Dieterich, Simon Schwager, Yuliang He, Kristian Ikenberg, Ekaterina Friebel, Burkhard Becher, Sònia Tugues, Michael Detmar
Abstract
LN macrophages in breast cancer metastasis and raise caution for the use of drugs aiming at the depletion of tumor-associated macrophages, which might simultaneously deplete macrophages in tumor-draining LNs.
Topics & Concepts
MacrophageMetastasisCancer researchLymph nodeLymphBreast cancerCancerMedicineMacrophage-activating factorMetastatic breast cancerPathologyCellImmunologyChemistryInternal medicineIn vitroBiochemistryImmune cells in cancerChemokine receptors and signalingCancer Immunotherapy and Biomarkers