PDE4D binds and interacts with YAP to cooperatively promote HCC progression
Huili Ren, Yingxiang Chen, Ao Zhou, Qi Cheng, Xiaoyan Yang, Hua Tao, Lixin Zhao, Ao Shen, Peiyuan Li, Qin Fu
Topics & Concepts
RoflumilastGene silencingCancer researchCell growthMAPK/ERK pathwayPhosphorylationChemistryPhosphodiesteraseCell biologySignal transductionKinaseBiologyInternal medicineBiochemistryMedicineEnzymeGeneCOPDHippo pathway signaling and YAP/TAZPhosphodiesterase function and regulationProtein Kinase Regulation and GTPase Signaling