Synthesis and Characterization of Functionalized Amino Dihydropyrimidines Toward the Analysis of their Antibacterial Structure–Activity Relationships and Mechanism of Action
Zachary W. Boyer, Hannah Kessler, Hannah Brosman, Kirsten J. Ruud, Alan F. Falkowski, Constance Viollet, Christina R. Bourne, Matthew C. O’Reilly
Abstract
biochemical and biophysical studies performed alongside the synergy assays call the antibacterial mechanism into question, indicating that further studies will be required to fully evaluate the antibacterial potential of this compound class.
Topics & Concepts
Antibacterial activityDihydrofolate reductaseMechanism of actionBiochemistryChemistryEnzymeBacteriaAntibioticsCombinatorial chemistryAntimicrobialIn vitroStereochemistryBiologyOrganic chemistryGeneticsMulticomponent Synthesis of HeterocyclesQuinazolinone synthesis and applicationsSynthesis and biological activity