Maintenance of the branched-chain amino acid transporter LAT1 counteracts myotube atrophy following chemotherapy
Stephen Mora, Olasunkanmi A. J. Adegoke
Abstract
This is the first study to attenuate chemotherapy-induced myotube atrophy by manipulating a BCAA transporter. Our findings suggest that positive regulation of amino acid transporters may be a promising strategy to treat cachexia.
Topics & Concepts
CachexiaChemotherapyMyogenesisWastingMuscle atrophyMyosinmTORC1AnabolismEndocrinologyInternal medicinePharmacologyChemistryCancer researchBiochemistryMedicinePhosphorylationCancerSkeletal muscleProtein kinase BMuscle Physiology and DisordersMuscle metabolism and nutritionGenetic Neurodegenerative Diseases