Persistent luminescent metal–organic framework nanocomposite enables autofluorescence-free dual modal imaging-guided drug delivery
Gang Shu, Huaixin Zhao, Xuening Zhang
Abstract
dual-modal imaging of tumor-bearing mice by providing high spatial resolution MR imaging and autofluorescence-free NIR imaging. The porous MIL-100(Fe) shell provides PLNPs@MIL-100(Fe) with up to 87.1% drug loading capacity and acid-triggered drug release for drug delivery. We envision that the proposed PLNPs@MIL-100(Fe) platform would provide an effective approach for precise tumor imaging and versatile drug delivery.
Topics & Concepts
AutofluorescenceLuminescenceNanocompositeDrug deliveryDual layerMetal-organic frameworkChemistryMaterials scienceLayer (electronics)FluorescenceNanotechnologyBiomedical engineeringOpticsOptoelectronicsMedicineAdsorptionOrganic chemistryPhysicsNanoplatforms for cancer theranosticsLuminescence and Fluorescent MaterialsMetal-Organic Frameworks: Synthesis and Applications