Photoredox‐Catalyzed Redox‐Neutral Minisci C−H Formylation of <i>N</i>‐Heteroarenes
Jianyang Dong, Xiaochen Wang, Hongjian Song, Yuxiu Liu, Qingmin Wang
Abstract
Abstract We report a protocol for redox‐neutral Minisci C−H formylation of N ‐heteroarenes using 1,3‐dioxoisoindolin‐2‐yl 2,2‐diethoxyacetate as a formyl equivalent at room temperature. This scalable benchtop protocol offers a distinct advantage over traditional reductive carbonylation and Minisci C−H formylation methods in not requiring the use of carbon monoxide, pressurized gas, a stoichiometric reductant, or a stoichiometric oxidant. magnified image
Topics & Concepts
FormylationChemistryCarbonylationStoichiometryCarbon monoxideRedoxCatalysisPhotochemistryCombinatorial chemistryInorganic chemistryOrganic chemistryCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsOxidative Organic Chemistry Reactions