MBD2 serves as a viable target against pulmonary fibrosis by inhibiting macrophage M2 program
Yi Wang, Lei Zhang, Guorao Wu, Qing Zhou, Huihui Yue, Lizong Rao, Ting Yuan, Biwen Mo, Faxi Wang, Longmin Chen, Fei Sun, Jia Song, Fei Xiong, Shu Zhang, Qilin Yu, Ping Yang, Yongjian Xu, Jianping Zhao, Huilan Zhang, Weining Xiong, Cong‐Yi Wang
Abstract
siRNA protected mice from BLM-induced lung injuries and fibrosis. Together, our data support the possibility that MBD2 could be a viable target against PF in clinical settings.
Topics & Concepts
BleomycinMacrophagePulmonary fibrosisCancer researchFibrosisLungIdiopathic pulmonary fibrosisImmunologyMedicineEndoplasmic reticulumChemistryBiologyCell biologyPathologyInternal medicineChemotherapyBiochemistryIn vitroInterstitial Lung Diseases and Idiopathic Pulmonary FibrosisMedical Imaging and Pathology StudiesNeonatal Respiratory Health Research