Identification of novel aminopyrimidine derivatives for the treatment of mutant NSCLC
Liping Hu, Shengmin Shi, Xiaomeng Song, Fangli Ma, Oulian Ji, Baohui Qi
Topics & Concepts
PharmacophoreChemistryT790MAllosteric regulationOsimertinibIC50ApoptosisCell cycle checkpointMutantCell cultureStereochemistryEGFR inhibitorsDocking (animal)Cell growthCell cyclePharmacologyEpidermal growth factor receptorBiochemistryIn vitroReceptorErlotinibMedicineGeneBiologyGefitinibGeneticsNursingLung Cancer Treatments and MutationsPI3K/AKT/mTOR signaling in cancerMultiple Myeloma Research and Treatments