Pharmacokinetic Modeling of (<i>R</i>)-[<sup>11</sup>C]verapamil to Measure the P-Glycoprotein Function in Nonhuman Primates
Lara García-Varela, David Vállez García, Takeharu Kakiuchi, Hiroyuki Ohba, Shingo Nishiyama, Tetsuro Tago, Philip H. Elsinga, Hideo Tsukada, Nicola Antonio Colabufo, Rudi Dierckx, Aren van Waarde, Jun Toyohara, Ronald Boellaard, Gert Luurtsema
Abstract
, calculated with 1-TCM and using short PET scans (10 to 30 min), as a suitable parameter to measure the P-gp function at the BBB of nonhuman primates.
Topics & Concepts
VerapamilPharmacokineticsP-glycoproteinPositron emission tomographyAkaike information criterionPharmacologyBlood samplingChemistryNuclear medicineMedicineInternal medicineCalciumBiochemistryMathematicsMultiple drug resistanceAntibioticsStatisticsDrug Transport and Resistance MechanismsPharmacological Effects and Toxicity StudiesEpilepsy research and treatment