Neutrophil extracellular traps aggravate neuronal apoptosis and neuroinflammation via neddylation after traumatic brain injury
Xianghua Zhang, Jianye Xu, Yonggang Fan, Guihong Shi, Bo Chen, Anni Wang, Yanlin Zhu, Lei Li, Haoran Jia, Dilmurat Gheyret, Jinchao Wang, Yiyao Cao, Shenghui Li, Xin Chen, Jianning Zhang, Shu Zhang
Abstract
Our study revealed that NETs trigger neuronal death and neuroinflammation via neddylation. We propose that inhibiting neddylation could offer therapeutic benefits in TBI.
Topics & Concepts
NeuroinflammationTraumatic brain injuryNeutrophil extracellular trapsExtracellularApoptosisNeddylationMicrogliaInflammationMedicineNeuroscienceCell biologyChemistryBiologyImmunologyUbiquitin ligaseBiochemistryGeneUbiquitinPsychiatryNeutrophil, Myeloperoxidase and Oxidative MechanismsTraumatic Brain Injury and Neurovascular DisturbancesNeurological Disorders and Treatments