A UVB-responsive common variant at chromosome band 7p21.1 confers tanning response and melanoma risk via regulation of the aryl hydrocarbon receptor, AHR
Mai Xu, Lindsey Mehl, Tongwu Zhang, Rohit Thakur, Hayley Sowards, Timothy A. Myers, Lea Jessop, Alessandra Chesi, Matthew E. Johnson, Andrew D. Wells, Helen Michael, Patricia Bunda, Kristine Jones, Herbert Higson, Rebecca C. Hennessey, Ashley Jermusyk, Michael A. Kovacs, Maria Teresa Landi, Mark M. Iles, Alisa M. Goldstein, Jiyeon Choi, Stephen J. Chanock, Struan F.A. Grant, Raj Chari, Glenn Merlino, Matthew H. Law, Kevin M. Brown
Topics & Concepts
Aryl hydrocarbon receptorBiologyGenome-wide association studyExpression quantitative trait lociGeneticsAlleleLocus (genetics)Cancer researchGeneTranscription factorGenotypeSingle-nucleotide polymorphismmelanin and skin pigmentationSkin Protection and AgingCarcinogens and Genotoxicity Assessment