Rapid deracemization through solvent cycling: proof-of-concept using a racemizable conglomerate clopidogrel precursor
Sjoerd W. van Dongen, Iaroslav Baglai, Michel Leeman, Richard M. Kellogg, Bernard Kaptein, Willem L. Noorduin
Abstract
We demonstrate that a conglomerate-forming clopidogrel precursor undergoing solution phase racemization can be deracemized through cyclic solvent removal and re-addition. We establish that the combination of slow growth and fast dissolution of crystals is ideal for rapid deracemization, which we achieve by repurposing a Soxhlet apparatus to realize the slow removal and fast re-addition of solvent autonomously.
Topics & Concepts
RacemizationDissolutionSolventRepurposingConglomerateChemistryPhase (matter)Combinatorial chemistryChemical engineeringMaterials scienceOrganic chemistryBiologyEcologySedimentary rockEngineeringPaleontologyOrigins and Evolution of LifeCrystallization and Solubility StudiesEnzyme Structure and Function