Cannabinoids drive Th17 cell differentiation in patients with rheumatic autoimmune diseases
Konstantin Kotschenreuther, Iris Waqué, Shuaifeng Yan, Anja Meyer, T. Haak, Julia von Tresckow, Joanna Schiller, Lydia Gloyer, Mara Dittrich-Salamon, David M. Kofler
Abstract
Background!#!A remarkably better prognosis is associated with oropharyngeal squamous cell carcinomas (OPSCC) driven by human papillomaviruses (HPV) compared with HPV-negative OPSCC. Consequently, de-escalation of standard treatment has been suggested. Due to modest specificity rates, debates are ongoing, whether p16!##!Methods!#!We assessed a large-scale cohort of consecutively included OPSCC diagnosed between 2000 and 2017 for HPV-DNA, HPV genotypes, p16!##!Results!#!Aetiological relevance of HPV (p16!##!Conclusions!#!p16
Topics & Concepts
MedicineImmunologyAutoimmune diseaseCellular differentiationBiologyGeneticsGeneAntibodyCannabis and Cannabinoid ResearchDiabetes and associated disordersDiabetes Management and Research