NDTP Mediated Direct Rapid Amide and Peptide Synthesis without Epimerization
Yiping Li, Jingyue Li, Guangjun Bao, Changjun Yu, Yuyang Liu, Zeyuan He, Peng Wang, Wen Ma, Junqiu Xie, Wangsheng Sun, Rui Wang
Abstract
Herein, we explored an unprecedented mild, nonirritating, conveniently available, and recyclable coupling reagent NDTP, which could activate the carboxylic acids via acyl thiocyanide and enable the rapid amide and peptide synthesis at very mild conditions. In addition, the methodology was compatible with Fmoc-SPPS, which may provide an alternative to peptide manufacturing.
Topics & Concepts
ChemistryEpimerAmideReagentCombinatorial chemistryPeptidePeptide synthesisOrganic chemistryBiochemistryChemical Synthesis and AnalysisChemical Synthesis and ReactionsAdvanced Synthetic Organic Chemistry