Universal endogenous antibody recruiting nanobodies capable of triggering immune effectors for targeted cancer immunotherapy
Haofei Hong, Chen Li, Liang Gong, Jinfeng Wang, Dan Li, Jie Shi, Zhifang Zhou, Zhaohui Huang, Zhimeng Wu
Abstract
Universal endogenous antibody recruiting nanobodies (UEAR Nbs), composed of IgGs binding domain and nanobody, could redirect endogenous IgGs onto target cell surfaces and evoke potent immune responses to eliminate cancer cells <italic>in vitro</italic> and <italic>in vivo</italic>.
Topics & Concepts
Cancer immunotherapyEffectorImmune systemImmunotherapyAntibodyImmunologyCancerEndogenyBiologyCancer researchGeneticsEndocrinologyMonoclonal and Polyclonal Antibodies ResearchGlycosylation and Glycoproteins ResearchImmunotherapy and Immune Responses