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Discovery of a covalent inhibitor of heat shock protein 90 with antitumor activity that blocks the co-chaperone binding via C-terminal modification

Li Li, Nannan Chen, Dandan Xia, Shicheng Xu, Wei Dai, Yuanyuan Tong, Lei Wang, Zhengyu Jiang, Qidong You, Xiaoli Xu

2021Cell chemical biology18 citationsDOI

Topics & Concepts

Hsp90Chaperone (clinical)Covalent bondCDC37Heat shock proteinBiochemistryCell biologyChemistryBiologyOrganic chemistryMedicinePathologyGeneHeat shock proteins researchComputational Drug Discovery Methods
Discovery of a covalent inhibitor of heat shock protein 90 with antitumor activity that blocks the co-chaperone binding via C-terminal modification | Litcius