Bivalent inhibitors of the BTB E3 ligase KEAP1 enable instant NRF2 activation to suppress acute inflammatory response
Mengchen Lu, Jianai Ji, Yifei Lv, J. Zhao, Yuting Liu, Qiong Jiao, Tian Liu, Yi Mou, Qidong You, Zhengyu Jiang
Topics & Concepts
Ubiquitin ligaseKEAP1UbiquitinDNA ligaseChemistryInflammationProinflammatory cytokineTranscription factorCell biologyBiochemistryImmunologyBiologyEnzymeGeneGenomics, phytochemicals, and oxidative stressMacrophage Migration Inhibitory FactorHistone Deacetylase Inhibitors Research