Macrophage-mediated tumor homing of hyaluronic acid nanogels loaded with polypyrrole and anticancer drug for targeted combinational photothermo-chemotherapy
Tingting Xiao, Wei Hu, Yu Fan, Mingwu Shen, Xiangyang Shi
Abstract
The developed hybrid HA-based NG nanosystem incorporated with PPy and DOX fully integrates the coordination and heating property of PPy to regulate the optimized DOX release in the tumor region with the assistance of MA-mediated tumor homing, providing a promising cell therapy strategy for enhanced antitumor therapy.
Topics & Concepts
In vivoHoming (biology)Hyaluronic acidDoxorubicinPhotothermal therapyCancer researchIn vitroMaterials scienceChemotherapyTumor microenvironmentDrug deliveryChemistryPharmacologyNanotechnologyMedicineTumor cellsBiochemistryBiologySurgeryEcologyAnatomyBiotechnologyNanoplatforms for cancer theranosticsNanoparticle-Based Drug DeliveryImmune cells in cancer