IL-27 Counteracts Neuropathic Pain Development Through Induction of IL-10
Miriam M. Fonseca, Marcela Davoli-Ferreira, Flávia V. Santa-Cecília, Rafaela Mano Guimarães, Francisco Fábio Bezerra de Oliveira, Ricardo Kusuda, David Wilson Ferreira, José C. Alves‐Filho, Fernando Q. Cunha, Thiago M. Cunha
Abstract
mice. These results provided evidence that IL-27 is a cytokine produced after peripheral nerve injury that counteracts neuropathic pain development through induction of the antinociceptive cytokine IL-10. In summary, our study unraveled the role of IL-27 as a regulatory cytokine that counteracts the development of neuropathic pain after peripheral nerve damage. In conclusion, they indicate that immunotherapies based on IL-27 could emerge as possible therapeutic approaches for the prevention of neuropathic pain development after peripheral nerve injury.