Micro- to nano-scale chemical and mechanical mapping of antimicrobial-resistant fungal biofilms
Duy Quang Pham, Saffron J. Bryant, Samuel Cheeseman, Louisa Z. Y. Huang, Gary Bryant, Madeleine Dupont, James Chapman, Christopher C. Berndt, Jitraporn Vongsvivut, Russell J. Crawford, Vi Khanh Truong, Andrew Siao Ming Ang, Aaron Elbourne
Abstract
C. neoformans). A new experimental methodology of characterization is proposed, employing a combination of atomic force microscopy (AFM), instrumented nanoindentation, and Synchrotron ATR-FTIR measurements. This allowed the nano-mechanical and chemical characterisation of each fungal biofilm.
Topics & Concepts
NanoindentationBiofilmAntimicrobialAtomic force microscopyMaterials scienceNanotechnologyNano-Nanoscopic scaleMicrobiologyBacteriaComposite materialBiologyGeneticsBacterial biofilms and quorum sensingForce Microscopy Techniques and ApplicationsAntimicrobial Peptides and Activities