Probiotic strains alleviated OVA-induced food allergy in mice by regulating the gut microbiota and improving the level of indoleacrylic acid in fecal samples
Wenwei Lu, Qian Li, Zhifeng Fang, Hongchao Wang, Jinlin Zhu, Yuan Kun Lee, Jianxin Zhao, Hao Zhang, Wei Chen
Abstract
CCFM1190 improved indoleacrylic acid levels in mouse fecal samples using untargeted metabolomics analysis. In conclusion, CCFM1189, CCFM1190, and CCFM1029 decreased Th2 immune responses and alleviated FA pathological symptoms by regulating the gut microbiota diversity and composition, and altering gut microbial metabolites, which could provide support in clinical tests and probiotic production in the future.
Topics & Concepts
ProbioticGut floraLactobacillus reuteriBifidobacteriumBiologyImmune systemMicrobiologyBifidobacterium animalisLactobacillus plantarumBifidobacterium breveDysbiosisFood scienceLactobacillusBacteriaImmunologyLactic acidFermentationGeneticsGut microbiota and healthProbiotics and Fermented FoodsDermatology and Skin Diseases