Zn(<scp>ii</scp>)-catalysed enantioselective addition of alcohols and <i>tert</i>-butyl hydroperoxide to isatin-derived <i>N</i>-Boc ketimines
Jiaqi Hou, Leipeng Xue, Tianxu Yu, Jiahui Li, Shibo Yu, Chao Yao, Yue‐Ming Li
Abstract
-aminals in up to 99% yield and up to 99% ee. The reactions could be carried out under mild conditions and a gram-scale reaction could be realized without the loss of the yield and enantioselectivity.
Topics & Concepts
IsatinChemistryYield (engineering)Enantioselective synthesisOrganic chemistrytert-Butyl hydroperoxideProlineCatalysisMedicinal chemistryAmino acidBiochemistryMaterials scienceMetallurgyAsymmetric Synthesis and CatalysisAsymmetric Hydrogenation and CatalysisSynthetic Organic Chemistry Methods