A dynamic cascade DNA nanocomplex to synergistically disrupt the pyroptosis checkpoint and relieve tumor hypoxia for efficient pyroptosis cancer therapy
Xiaoni Wang, Xiyang Ge, Min Zhang, Jianghui Sun, Jin Ouyang, Na Na
Abstract
A DNA nanocomplex with cascade DNAzymes, promoter-like ZnO 2 –Mn nanozymes and intercalated photosensitizers was designed to synergistically disrupt autophagy and relieve tumor hypoxia for efficient pyroptosis therapy.
Topics & Concepts
PyroptosisHypoxia (environmental)Cancer therapyCancer researchCancerChemistryMedicineApoptosisProgrammed cell deathInternal medicineBiochemistryOxygenOrganic chemistryNanoplatforms for cancer theranosticsInflammasome and immune disordersToxoplasma gondii Research Studies