Oxalate Nephropathy Caused by Excessive Vitamin C Administration in 2 Patients With COVID-19
Francesco Fontana, Silvia Cazzato, Silvia Giovanella, Marco Ballestri, Marco Leonelli, Giacomo Mori, Gaetano Alfano, Giulia Ligabue, Riccardo Magistroni, Giovanna Cenacchi, Riccardo Antoniotti, Decenzio Bonucchi, Gianni Cappelli
Abstract
Kidney dysfunction is frequently reported in patients with coronavirus disease 2019 (COVID-19). A recent large cohort study described an incidence of acute kidney injury (AKI) of 36% in patients who were hospitalized with COVID-19; AKI (often mild) was temporally linked with respiratory failure and associated with a poor prognosis.1 Many factors may be at play in determining kidney dysfunction in patients with COVID-19 who are critically ill; moreover, human kidneys have been reported as potential targets for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.