The role of ATP in cough hypersensitivity syndrome: new targets for treatment
Mengru Zhang, Shengyuan Wang, Li Yu, Xianghuai Xu, Zhongmin Qiu
Abstract
, ATP localizes within cells under normal physiological conditions, and has physiological functions, including in metabolism; however, under some pathological circumstances, ATP can act as a neuromodulator and is released into the extracellular space in large quantities as a signal transduction molecule. In addition, ATP is involved in regulation of airway inflammation and the cough reflex. Here, we review the generation, release, and regulation of ATP during airway inflammation and its role in the etiology of cough hypersensitivity syndrome, including the potential underlying mechanism.
Topics & Concepts
Cough reflexMedicineChronic coughEtiologyReflexAirwayAdenosine triphosphateRefractory (planetary science)InflammationAnesthesiaImmunologyInternal medicineAsthmaBiologyAstrobiologyRespiratory and Cough-Related ResearchAsthma and respiratory diseasesNeuroscience of respiration and sleep