Berberine Reverses Breast Cancer Multidrug Resistance Based on Fluorescence Pharmacokinetics <i>In Vitro</i> and <i>In Vivo</i>
Ke Qian, Chaoyuan Tang, Liying Chen, Shuang Zheng, Yue Zhao, Lisha Ma, Li Xu, Luhui Fan, Jiandong Yu, Hongsheng Tan, Ya-lan Sun, Li-li Shen, Lu Yang, Qi Liu, Yun Liu, Yang Xiong
Abstract
< 0.05). Thus, the results illustrated that Ber can reverse MDR by inhibiting the efflux function of ATP-binding cassette transporters and downregulating their expression levels.
Topics & Concepts
In vivoEffluxP-glycoproteinMultiple drug resistancePharmacologyDoxorubicinBerberineIn vitroWestern blotMolecular biologyChemistryBiologyBiochemistryChemotherapyAntibioticsGeneticsBiotechnologyGeneDrug Transport and Resistance MechanismsBerberine and alkaloids researchCancer therapeutics and mechanisms