Antimicrobial Susceptibility Trends and Risk Factors for Antimicrobial Resistance in<i>Pseudomonas aeruginosa</i>Bacteremia: 12-Year Experience in a Tertiary Hospital in Korea
Jin Suk Kang, Chisook Moon, Seok Jun Mun, Jeong Eun Lee, Soon Ok Lee, Shinwon Lee, Sun Hee Lee
Abstract
BACKGROUND: bacteremia and identified risk factors of antimicrobial resistance. METHODS: bacteremia who were admitted to a tertiary hospital between January 2009 and October 2020 were retrospectively reviewed. Antibiotic resistance rates were compared among the time periods of 2009-2012, 2013-2016, and 2017-2020 and between the intensive care unit (ICU) and non-ICU setting. Empirical antimicrobial therapy was considered concordant, if the organism was susceptible to antibiotics in vitro, and discordant, if resistant. RESULTS: (XDRPA) were 24.7%, 35.9%, and 15.9%, respectively. XDRPA showed an increasing trend, and CRPA, MDRPA, and XDRPA were also gradually increasing in non-ICU setting. Previous exposure to fluoroquinolones and glycopeptides and urinary tract infection were independent risk factors associated with CRPA, MDRPA, and XDRPA. Previous exposure to carbapenems was an independent risk factor of CRPA. CRPA, MDRPA, and XDRPA were associated with discordant empirical antimicrobial therapy. CONCLUSION: bacteremia.