Computer-aided design of 1,4-naphthoquinone-based inhibitors targeting cruzain and rhodesain cysteine proteases
Leandro Rocha Silva, Ari Souza Guimarães, Jadiely do Nascimento, Igor José dos Santos Nascimento, Elany Barbosa da Silva, James H. McKerrow, Sílvia Helena Cardoso, Edeildo Ferreira da Silva‐Júnior
Topics & Concepts
ChemistryCysteineProteasesEnzyme inhibitorNaphthoquinoneCombinatorial chemistryBiochemistryStereochemistryEnzymeOrganic chemistryBioactive Compounds and Antitumor AgentsSynthesis and biological activityPharmacological Effects of Natural Compounds