The gene for the lysosomal protein LAMP3 is a direct target of the transcription factor ATF4
Thomas D. Burton, Anthony O. Fedele, Jianling Xie, Lauren Sandeman, Christopher G. Proud
Abstract
, representing the first identification of a gene for a lysosomal component whose expression is directly controlled by ATF4. This finding may provide a key link between stresses such as accumulation of unfolded proteins and modulation of autophagy, which removes them.
Topics & Concepts
TFEBATF4Transcription factorCell biologyBiologyTransactivationAutophagyBAG3LysosomeGene knockdownGeneBiochemistryEnzymeApoptosisAutophagy in Disease and TherapyEndoplasmic Reticulum Stress and DiseaseCellular transport and secretion