Chronic <i>Porphyromonas gingivalis</i> lipopolysaccharide induces adverse myocardial infarction wound healing through activation of CD8<sup>+</sup> T cells
Yusra Zaidi, Alexa Corker, Valeria Y. Vasileva, Kimberly Oviedo, Connor Graham, Kyrie Wilson, John Vincent Martino, Miguel Troncoso, Philip Broughton, Daria V. Ilatovskaya, Merry L. Lindsey, Kristine Y. DeLeon‐Pennell
Abstract
Although there is a well-documented link between periodontal disease and heart health, the mechanisms are unclear. Our study indicates that in response to circulating periodontal endotoxins, memory CD8 + T cells are activated, resulting in an acceleration of macrophage-mediated inflammation after MI. Blocking activation of effector CD8 + T cells had no effect on the macrophage numbers or wall thinning at post-MI day 1, indicating that this response was likely due in part to memory CD8 + T cells.
Topics & Concepts
Porphyromonas gingivalisCD8InflammationPeriodontitisMacrophageLipopolysaccharideCytotoxic T cellImmunologyEffectorChronic periodontitisMedicineBiologyInternal medicineImmune systemIn vitroBiochemistryOral microbiology and periodontitis researchImmune Response and InflammationAtherosclerosis and Cardiovascular Diseases