DDX41 is needed for pre- and postnatal hematopoietic stem cell differentiation in mice
Jing Ma, Nadim Mahmud, Maarten C. Bosland, Susan R. Ross
Abstract
Ddx41 knockout cells from fetal liver demonstrated that the expression of many genes associated with hematopoietic differentiation were altered. Furthermore, differential splicing of genes involved in key biological processes was observed. Our data reveal a critical role for DDX41 in HSPC differentiation and myeloid progenitor development, likely through regulating gene expression programs and splicing.
Topics & Concepts
BiologyHaematopoiesisStem cellCell biologyCellular differentiationImmunologyGeneticsComputational biologyEvolutionary biologyCancer researchGeneAcute Myeloid Leukemia ResearchHematopoietic Stem Cell TransplantationZebrafish Biomedical Research Applications