Photoaffinity labeling identifies an intersubunit steroid-binding site in heteromeric GABA type A (GABAA) receptors
Selwyn S. Jayakar, David C. Chiara, Xiaojuan Zhou, Bo Wu, Karol S. Bruzik, Keith W. Miller, Jonathan B. Cohen
Abstract
subunit interface steroid-binding site and identify several steroid PAMs that act via other sites.
Topics & Concepts
Photoaffinity labelingPregnanoloneChemistryAllopregnanoloneAllosteric regulationGABAA receptorTransmembrane domainNeuroactive steroidDiazirineBinding siteStereochemistryConvulsantReceptorProtein subunitBiochemistryGeneNeuroscience and Neuropharmacology ResearchReceptor Mechanisms and SignalingNicotinic Acetylcholine Receptors Study