Structural Elucidation and Antimicrobial Characterization of Novel Diterpenoids from <i>Fabiana densa</i> var. <i>ramulosa</i>
Deborah Quaglio, Silvia Corradi, Silvia Erazo, Valeria Vergine, Simone Berardozzi, Fabio Sciubba, Floriana Cappiello, Maria Elisa Crestoni, Fiorentina Ascenzioni, Francesco Imperi, Franco Delle Monachè, Mattia Mori, Maria Rosa Loffredo, Francesca Ghirga, Bruno Casciaro, Bruno Botta, Maria Luisa Mangoni
Abstract
Novel diterpenoids were isolated from the extracts of Fabiana densa var. ramulosa and found to display a selective activity against Gram-positive bacterial strains with negligible cytotoxicity toward human keratinocytes. This study highlighted the role played by the acidic group at C18 of the tetracyclic ent-beyerene scaffold for antibacterial effects and how the length and flexibility of the alkyl chain between the two carbonyl groups are crucial factors to increase the antimicrobial activity of the molecules, supporting the development of natural products from F. densa and their derivatives for treatment of microbial infections.