<p>Toll-Like Receptor 4 and Inflammatory Micro-Environment of Pancreatic Islets in Type-2 Diabetes Mellitus: A Therapeutic Perspective</p>
Zhaoping Wang, Xiaolin Ni, Li Zhang, Liang Sun, Xiaoquan Zhu, Qi Zhou, Ze Yang, Huiping Yuan
Abstract
Patients with type-2 diabetes mellitus (T2DM) display chronic low-grade inflammation induced by activation of the innate immune system. Toll-like receptor (TLR)4 is a pattern recognition receptor that plays a vital part in activation of the innate immune system. Results from animal and computer-simulation studies have demonstrated that targeting TLR4 to block the TLR4-nuclear factor-kappa B (NF-κB) pathway reduces the inflammatory response and complications associated with T2DM. Therefore, TLR4-targeted therapy has broad prospects. Here, we reviewed the role of TLR4 in inflammation during chronic hyperglycemia in T2DM and its therapeutic prospects.
Topics & Concepts
TLR4InflammationToll-like receptorInnate immune systemMedicineReceptorImmune systemType 2 Diabetes MellitusImmunologyTollDiabetes mellitusInternal medicineEndocrinologyImmune Response and InflammationDiabetes and associated disordersAdipokines, Inflammation, and Metabolic Diseases