Lactate-induced mtDNA Accumulation Activates cGAS-STING Signaling and the Inflammatory Response in Sjögren's Syndrome
Jiabao Xu, Changyu Chen, Junhao Yin, Jiayao Fu, Xiujuan Yang, Baoli Wang, Chuangqi Yu, Lingyan Zheng, Zhiyuan Zhang
Abstract
by the lactate scavenger sodium dichloroacetate (DCA). Our study provides new insights into the etiology and treatment of pSS from the perspective of cell metabolism.
Topics & Concepts
In vivoMitochondrionCytokineAtrophyCell biologyIn vitroMitochondrial ROSBiologyChemistryInternal medicineEndocrinologyImmunologyBiochemistryMedicineBiotechnologyinterferon and immune responsesImmune cells in cancerImmune Response and Inflammation